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          首页» 课题组» 应用化学» 刘志博

          放射化学? PET活体成像

          刘志博 博士


          2016.07-至今,特聘研究员,北京大学化学与分子工程学院
          2016.07-至今,中心研究员,北大-清华生命科学联合中心
          2014.09–2016.07,博士后研究员,美国国立卫生研究院
          2010.09–2014.09,博士,英属哥伦比亚大学化学系
          2011.05–2014.09,跨学科博士培养项目,TRIUMF原子能国家实验室
          2012.03–2014.09,跨学科博士培养项目,英属哥伦比亚肿瘤中心
          2010.06,理学学士,南京大学化学化工学院化学系

          电话:86-10-62759191
          电子邮件:
          zbliu@pku.edu.cn
          课题组网页:www.naetnyc.com/zliu/

          研究兴趣:

          PET影像开辟了在分子层面上进行疾病诊断的新思路,它是精准医疗的排头兵。 近来,PET分子影像已成为了我国各大医院的常规检查项目,市场份额在2015年超过了100亿元。与X射线、CT及MRI等传统临床影像不同, PET影像的诊断效果依赖于放射性标记的分子探针。但是,由于放射化学的特殊性以及多学科融合的复杂性,我国在PET分子探针上的基础研究还相对落后,与国际先进水平差距巨大。即使是国内顶尖的医疗机构,也不得不从国外引进PET探针,辅助国内的临床研究。回国之后,我们计划在北大化院、北大-清华生命联合中心以及周边医学院所的支持下,搭建起我国第一个立足基础研究的PET分子影像平台,填补国内空白,切实推动我国精准医疗事业的发展。
          主要的研究方向如下: 
          1. 以B-F键为基础的18F通用标记法
          2. 以三氟化硼(-BF3-)与羧酸根(-COO-)的相似性为基础的化学生物学研究
          3. 以炎症特异性的放射性探针为基础,采用PET影像支持临床中癌症与炎症的鉴别
          4. 以硼中子捕获治疗(BNCT)为基础的癌症诊疗一体化平台

          所获奖励:

          2016.06, Distinguished Scientist Award, NIH-CSSA Committee 
          2015.06, Michael J. Welch Postdoctoral Award, Society of Nuclear Medicine and Molecular Imaging
          2015.06, JNM Editor’s Choice Award, Society of Nuclear Medicine and Molecular Imaging
          2015.04, Alavi-Mandell Award, Society of Nuclear Medicine and Molecular Imaging
          2014.08, Edward Piers Memorial Award, Edward Piers Foundation
          2014.06, Chinese Government Award for Outstanding Abroad Students, China Scholarship Council
          2014.05, SNMMI Travel Award, Society of Nuclear Medicine and Molecular Imaging
          2013.08, Scholar Travel Award, 23rd American Peptide Symposium 
          2013.06, Young Investigator Award, 37th CASNM
          2013.05, SRS Travel Bursary, 20th ISRS
          2013.05, Graduate Student Travel Award, Chemistry Department, UBC
          2013.02, Boehringer Ingelheim Scholarship, Boehringer Ingelheim Foundation 

           

          代表文章

          1. Zhibo Liu*, Xiaoyuan Chen* Simple Bioconjugate Chemistry Serves Great Clinical Advances: Albumin as A Versatile Platform for Diagnosis and Precision Therapy.Chem. Soc. Rev., 2016, 45, 1432-1456 (*corresponding author)
          2. Zhibo Liu*, Haojun Chen, Kai Chen, Yihan Shao, Dale O. Kiesewetter, Gang Niu, Xiaoyuan Chen* Boramino Acid as A Marker for Amino Acid Transporter. Science Advances, 2015;1:e1500694 (*corresponding author, highlighted on C&EN News)
          3. Zhibo Liu*, Kuo-Shyan Lin, Fran?ois Bénard, Dale O. Kiesewetter, David M. Perrin*, Xiaoyuan Chen* A Broadly Applicable One-step 18F-Labeling Protocol with Organotrifluoroborates. Nat. Protoc, 2015, 10, 1423–1432 (*corresponding author)
          4. Zhibo Liu, Daniel Chao, Ying Li, Richard Ting, Jihyoon Oh, David M. Perrin From Minutes to Years: Predicting Solvolysis Rates for Organotrifluoroborates, Chem. Eur. J., 2015, 21, 3924-3928
          5. Zhibo Liu, Maral Pourghiasian, Gemma Dias, Joseph Lau, Francois Benard, Kuo-shyan Lin, David M. Perrin, An Organotrifluoroborate for Broadly Applicable One-Step 18F-Labeling, Angew. Chem. Int. Ed., 2014, 53, 11876–11880 (Cover feature, highlighted on C&EN News)
          6. Zhibo Liu, Mark Alex Radtke, May Q. Wong, Kuo-Shyan Lin, Donald Yapp, David M. Perrin, Dual Mode Fluorescent PET Tracers: Efficient modular synthesis of Rhodamine-[cRGD]2-Alkyl-18F-Trifluoroborate, Rapid 18F-labeling at very high specific activity, In vivo PET Imaging, and Ex vivo fluorescence,Bioconjugate Chem. 2014, 25, 1951–1962 (Cover feature)
          7. Zhibo Liu, Maral Pourghiasian, Francois Benard, Jinhe Pan, Kuo-Shyan Lin, David M. Perrin, Preclinical Evaluation of A High Affinity 18F-Trifluorborate Octreotide Derivative for Somatostatin Receptor Imaging, J Nucl Med., 2014, 55, 1499-1505 (JNM Editor’s Choice Award)
          8. Zhibo Liu, Ying Li, Jerome Lozada, Paul Schaffer, Michael J. Adam, Thomas J. Ruth, David M. Perrin, Stoichiometric Leverage: Rapid 18F-Aryltrifluoroborate Radiosynthesis at Exceptionally High Specific Activity For Click Conjugation, Angew. Chem. Int. Ed., 2013, 52, 2303-2307.
          9. Zhibo Liu, Ying Li, Jerome Lozada, May Q. Wong, Jennifer Greene, Kuo-Shyan Lin, Donald Yapp, David M. Perrin, Kit-like 18F-labeling of RGD-19F-Arytrifluroborate in High Yield and at Extraordinarily High Specific Activity with Preliminary In Vivo Tumor Imaging, Nucl Med Biol, 2013, 40, 841-849.
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